If you aren't into social media, you'll find this particularly funny.
Ironically, social media is one of the reasons that this skit has become so popular. Yes, Conan has a significant reach. But it has become compounded as people share this viral video through YouTube, blogging, twittering, etc. Viral video can be powerful, can you think of one for your business?
Oh, if you watch this and have the grand idea to go buy the URL youtwitface.com, it is already taken. And t-shirt sales for the site are taken too.